Antituberculous composition and method for preparing the same



【課題】バイオアベイラビリティに優れたリファンピシン及びイソニアジドを含む経口用抗結核剤を提供する。 【解決手段】リファンピシンは、直ちに放出する形体で製剤化され、胃において実質的に放出され、イソニアジドは、フタル酸酢酸セルロース、ヒドロキシプロピルメチルセルロースフタレート、ポリ酢酸ビニルフタレート、ヒドロキシプロピルメチルセルロース酸スクシネート、アルギン酸、メタクリル酸ポリマー、カルボマー、ポラクリリンカリウム、シェラック又はキトサンのpH感受性ポリマーで徐放性剤形に製剤化される。リファンピシン及びイソニアジドは、放出後、胃の酸性胃内容物において、液状で、相互に接触しない。 【選択図】なし
<P>PROBLEM TO BE SOLVED: To provide oral antituberculous agent containing rifampicin and isoniazid having excellent bioavailability. <P>SOLUTION: The rifampicin is formed into a preparation in an immediately releasing form and substantially released at the stomach, and the isoniazid is formed into a preparation in a controlled release form by a pH-sensitive polymer of a cellulose phthalate acetate, a hydroxypropylcellulose phthalate, a polyvinyl acetate phthalate, a hydroxypropylmethylcellulose acid succinate, alginic acid, a methacrylic acid polymer, a carbomer, a polacrilin potassium, shellac or chitosan. The rifampicin and the isoniazid do not contact with each other in a liquid shape after the release in acidic gastric contents of the stomach. <P>COPYRIGHT: (C)2008,JPO&INPIT




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